Francis or Frank Brooke may refer to:
Francis T. Brooke (1763–1851), politician from Virginia
Francis Brooke (cricketer, born 1884) (1884–1960), English cricketer
Francis Brooke (cricketer, born 1810) (1810–1886), English cricketer and British Army officer
Francis Key Brooke (1852–1918), missionary bishop of what is now the Episcopal Diocese of Oklahoma
Frank Brooke (1851–1920), Anglo-Irish Director of Great Southern and Eastern Railways and a member of the Earl of Ypres' Advisory Council
Francis Brooke (economist), Acting Under Secretary for International Affairs of the US Department of the Treasury in 2026